|[Seminar] [Special Seminar] Prof. Sung-Yon Kim (SNU), 4/Feb/2021 "How do we stop eating when we are full?" (Feb 4, 2021)
Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut–brain communication pathways and mechanisms remain poorly understood. Here we show that, in mice, neurons in the parabrachial nucleus that express the prodynorphin gene (hereafter, PBPdyn neurons) monitor the intake of both fluids and solids, using mechanosensory signals that arise from the upper digestive tract. Most individual PBPdyn neurons are activated by ingestion as well as the stimulation of the mouth and stomach, which indicates the representation of integrated sensory signals across distinct parts of the digestive tract. PBPdyn neurons are anatomically connected to the digestive periphery via cranial and spinal pathways; we show that, among these pathways, the vagus nerve conveys stomach-distension signals to PBPdyn neurons....
|[Seminar] [Special Seminar] Prof. C. Justin Lee (IBS), 22/Jan/2021 "Ultrasonogenetic Neuromodulation via Astrocytic TRPA1" (Jan 22, 2021)
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1.
|[Event] President of Yonsei University visited IBS CNM (Nov 5, 2020)
On the 5th of November, 2020, the presidential delegation of Yonsei University, including Seoung Hwan Suh, the president visited IBS CNM. Jinwoo Choen, the director of IBS CNM greeted the delegation and gave a hall tour.
|[SF@Y] SF@Y Season 3! "Create NANO" (Sep 18, 2020)
Science Factory at Yonsei, Season 3, 2020 Summer
|[Event] The President of the IBS at IBS CNM (Aug 13, 2020)
Do Young Noh, the President of the Institute for Basic Science (IBS) visited IBS CNM
|[Event] IBS CNM with Institut Français Corée du Sud (Jul 28, 2020)
Science and Higher Education Officers of French Embassy(Institut Français Corée du Sud) visited IBS CNM to share passionate ideas with us
|[YouTube] Interview: Dr. Chang Yeol Lee (Jun 22, 2020)
IBS CNM Researcher Interview (1)
|[YouTube] IBS CNM & Nano BME Facility Introduction (Apr 17, 2020)
Laboratory tour with students and researchers of IBS CNM & Nano BME
|[YouTube] Interview: New students' Nano BME Life (Korean) (Apr 1, 2020)
Interview with new students of 2020. Find out how they think about Nano BME life!
|[SF@Y] SF@Y Season 2! The journey towards Challenge NANO (Mar 5, 2020)
Science Factory at Yonsei, Season 2, 2019 Winter