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Zongwen Jin, Young Ki Hahn, Eunkeu Oh, Je-Kyun Park, Seung Ho Moon,Jung-tak Jang, Jinwoo Cheon , Hak-Sung Kim
"Magnetic Nanoclusters for Ultrasensitive Magnetophoretic Assays"
Small, 5 (20), 2244-2246
Date: Oct 16, 2009

Magnetic nanoclusters (MNCs) are developed and used for an ultrasensitive magnetophoretic assay system. Prostateā€specific antigen (PSA) is used as a target analyte (see image). The deflection velocity of a microbead is well correlated with the PSA concentration, with a detection limit of 45 fg mL−1, and this value is three orders of magnitude higher than conventional ELISA. The developed assay format is expected to be effectively applied to the detection of a target analyte with low abundance.

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