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Dongwon Yoo, Heeyeong Jeong, Seung-Hyun Noh, Jae-Hyun Lee, and Jinwoo Cheon*
Magnetically Triggered Dual Functional Nanoparticles for Resistance-Free Apoptotic Hyperthermia
Angew. Chem. Int. Ed., 52 (49), 13047-13051
Date: Dec 2, 2013

Overcoming resistance: Heat‐treated cancer cells possess a protective mechanism for resistance and survival. Resistance‐free apoptosis‐inducing magnetic nanoparticles (RAINs) successfully promote hyperthermic apoptosis, obstructing cell survival by triggering two functional units of heat generation and the release of geldanamycin (GM) for heat shock protein (Hsp) inhibition under an alternating magnetic field (AMF).

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