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Nohyun Lee, Dongwon Yoo, Daishun Ling, Mi Hyeon Cho, Taeghwan Hyeon, and Jinwoo Cheon
"Iron Oxide Based Nanoparticles for Multimodal Imaging and Magnetoreponsive Therapy"
Chem. Rev., 115 (19), 10637-10689
Date: Aug 7, 2015

Magnetic nanoparticles have received tremendous attention in diverse fields because of their unique nanoscale physicochemical properties and the potential for a wide range of applications.(1-6) In particular, iron oxide nanoparticles have existed in nature, and some living systems, such as magnetotactic bacteria,(7, 8) fish,(9) and birds,(10) have been reported to utilize them for their navigation by recognizing the Earth’s magnetic field. Humans have used magnetic materials for various purposes from compasses to navigate to reach their destination to hard disks for storing a large amount of information.(11) NASA’s ferrofluid is another interesting application of magnetic nanoparticles, which is used as rotating shaft seals in space.(12) In the past decade, bottom-up chemical synthesis and applications of magnetic nanoparticles have been active areas of research in the fields of chemistry, chemical engineering, materials science, and biomedical sciences.(13-16) High quality magnetic nanoparticles can be synthesized by chemical methods, such as coprecipitation,(17) thermal decomposition,(18-20) sol–gel,(21) and hydrothermal reaction.(22) Compared to top-down approaches, these bottom-up methods enable the synthesis of uniformly sized nanoparticles to be useful in various applications,(23-25) such as data storage,(26) catalysis,(27) bioseparation,(28-30) and biosensing.(31-34)

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