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Yoonhee Jin, Jung-uk Lee, Eunna Chung, Kisuk Yang, Jin Kim, Ji-wook Kim, Jong Seung Lee, Ann-Na Cho, Taekyu Oh, Jae-Hyun Lee, Seung-Woo Cho*, and Jinwoo Cheon*
Magnetic Control of Axon Navigation in Reprogrammed Neurons
Nano Lett., 19 (9), 6517-6523
Date: Aug 28, 2019

While neural cell transplantation represents a promising therapy for neurodegenerative diseases, the formation of functional networks of transplanted cells with host neurons constitutes one of the challenging steps. Here, we introduce a magnetic guidance methodology that controls neurite growth signaling via magnetic nanoparticles (MNPs) conjugated with antibodies targeting the deleted in colorectal cancer (DCC) receptor (DCC-MNPs). Activation of the DCC receptors by clusterization and subsequent axonal growth of the induced neuronal (iN) cells was performed in a spatially controlled manner. In addition to the directionality of the magnetically controlled axon projection, axonal growth of the iN cells assisted the formation of functional connections with pre-existing primary neurons. Our results suggest magnetic guidance as a strategy for improving neuronal connectivity by spatially guiding the axonal projections of transplanted neural cells for synaptic interactions with the host tissue.

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