Cheon Lab

Main Links

Logo and Main Menu

Full Menu

Research

Yong-Min Huh, Young-wook Jun, Ho-Taek Song, Sungjun Kim, Jin-sil Choi, Jae-Hyun Lee, Sarah Yoon, Kyung-Sup Kim, Jeon-Soo Shin, Jin-Suck Suh*, and Jinwoo Cheon*
In Vivo Magnetic Resonance Detection of Cancer by Using Multifunctional Magnetic Nanocrystals
J. Am. Chem. Soc., 127 (35), 12387-12391
Date: Sep 1, 2005

The unique properties of magnetic nanocrystals provide them with high potential as key probes and vectors in the next generation of biomedical applications. Although superparamagnetic iron oxide nanocrystals have been extensively studied as excellent magnetic resonance imaging (MRI) probes for various cell trafficking, gene expression, and cancer diagnosis, further development of in vivo MRI applications has been very limited. Here, we describe in vivo diagnosis of cancer, utilizing a well-defined magnetic nanocrystal probe system with multiple capabilities, such as small size, strong magnetism, high biocompatibility, and the possession of active functionality for desired receptors. Our magnetic nanocrystals are conjugated to a cancer-targeting antibody, Herceptin, and subsequent utilization of these conjugates as MRI probes has been successfully demonstrated for the monitoring of in vivo selective targeting events of human cancer cells implanted in live mice. Further conjugation of these nanocrystal probes with fluorescent dye-labeled antibodies enables both in vitro and ex vivo optical detection of cancer as well as in vivo MRI, which are potentially applicable for an advanced multimodal detection system. Our study finds that high performance in vivo MR diagnosis of cancer is achievable by utilizing improved and multifunctional material properties of iron oxide nanocrystal probes.

 

Top 1% Cited Paper

[Oct. 29, 2005, vol 168, No 18, p280] 
Science News
[Aug. 22, 2005] 
Royal Society of Chemistry(RSC) Chemistry World
[Sep. 19, 2005] 
National Cancer Institute(NCI) Nanotech News
[Sep. 20, 2005] 
Nanotechnology News
[Oct. 1, 2005, Vol 77, No 19, p368A]
 Analytical Chemistry Monthly News

 

Copyright and Address

  • ADDRESS Department of Chemistry. 50 Yonsei-ro, Seodaemun-gu, Seoul 03722
  • TEL +82-2-2123-4769
  • FAX +82-2-2123-4640
  • EMAIL lee7626@yonsei.ac.kr
  • © Cheon Group | Yonsei University. All Right Reserved

Display Page Loading Image

Top