|[Seminar] [Special Seminar] Prof.Eui-Cheol Shin (KAIST&IBS), Nov/23/2021 "Phenotypes and functions of SARS-CoV-2-specific T cells" (Nov 15, 2021)
In this lecture, I will review immune responses against SARS-CoV-2 and VOCs. In particular, I will focus on SARS-CoV-2-specific CD4+ and CD8+ T cell responses that have been detected and characterized among not only COVID-19 patients and convalescents but also unexposed individuals. I will lecture on phenotypes and functions of SARS-CoV-2-specific T cells in COVID-19 patients and the relationships between SARS-CoV-2-specific T cell responses and the severity of COVID-19. In addition, I will lecture on phenotypes and functions of SARS-CoV-2-specific memory T cells after recovery from COVID-19. I will also discuss the presence of SARS-CoV-2-reactive T cells in unexposed individuals and SARS-CoV-2-specific T cell responses elicited by COVID-19 vaccination.
|[Seminar] [Special Seminar] Prof.Kwanghun Chung (MIT&Yonsei), Jul/06/2021 "Technologies for illuminating health and diseases: from ideas to impact" (Jun 30, 2021)
Understanding disease mechanisms and developing new therapeutic strategies requires holistic measurement of diverse anatomical and molecular traits that span multiple levels, from cells to an entire system. In this talk, I will discuss new technologies for studying organ-scale biological systems and how we can accelerate the technology adoption to maximize the impact.
|[Notice] 천진우 교수, 연세대학교 우수업적교수상 최우수상 수상 (Jun 7, 2021)
천진우 단장님이 탁월한 연구 업적으로 2020학년도 연세대학교 우수업적교수로 선정되셨습니다....
|[Seminar] [Special Seminar] Prof. Jayoung Kim (Yonsei), 23/Mar/2021 "Wearable biosensors for healthcare applications (Mar 17, 2021)
Wearable biosensors represent a promising opportunity to continuously and non-invasively track human physiology through dynamic measurements of chemical markers in bio-fluids such as sweat, tears, saliva and interstitial fluid. Such biosensing platforms can thus offer real-time biochemical information toward a more comprehensive view of a wearer’s health, performance or stress at the molecular level. The growing recent interest in wearable and mobile technologies has led to increased research efforts toward development of non-invasive biomarker monitoring platforms. Continuous biomonitoring addresses the limitations of finger-stick blood testing and provides the opportunity for optimal therapeutic interventions. The research during PhD is focused on developing wearable sensors and biosensors along with non-invasive biosensing opportunities and the potential impact of such wearable devices on our daily life....
|[Seminar] [Special Seminar] Prof. Sung-Yon Kim (SNU), 4/Feb/2021 "How do we stop eating when we are full?" (Feb 4, 2021)
Mechanosensory feedback from the digestive tract to the brain is critical for limiting excessive food and water intake, but the underlying gut–brain communication pathways and mechanisms remain poorly understood. Here we show that, in mice, neurons in the parabrachial nucleus that express the prodynorphin gene (hereafter, PBPdyn neurons) monitor the intake of both fluids and solids, using mechanosensory signals that arise from the upper digestive tract. Most individual PBPdyn neurons are activated by ingestion as well as the stimulation of the mouth and stomach, which indicates the representation of integrated sensory signals across distinct parts of the digestive tract. PBPdyn neurons are anatomically connected to the digestive periphery via cranial and spinal pathways; we show that, among these pathways, the vagus nerve conveys stomach-distension signals to PBPdyn neurons....
|[Seminar] [Special Seminar] Prof. C. Justin Lee (IBS), 22/Jan/2021 "Ultrasonogenetic Neuromodulation via Astrocytic TRPA1" (Jan 22, 2021)
Low-intensity, low-frequency ultrasound (LILFU) is the next-generation, non-invasive brain stimulation technology for treating various neurological and psychiatric disorders. However, the underlying cellular and molecular mechanism of LILFU-induced neuromodulation has remained unknown. Here, we report that LILFU-induced neuromodulation is initiated by opening of TRPA1 channels in astrocytes. The Ca2+ entry through TRPA1 causes a release of gliotransmitters including glutamate through Best1 channels in astrocytes. The released glutamate activates NMDA receptors in neighboring neurons to elicit action potential firing. Our results reveal an unprecedented mechanism of LILFU-induced neuromodulation, involving TRPA1 as a unique sensor for LILFU and glutamate-releasing Best1 as a mediator of glia-neuron interaction. These discoveries should prove to be useful for optimization of human brain stimulation and ultrasonogenetic manipulations of TRPA1.
|[Event] President of Yonsei University visited IBS CNM (Nov 5, 2020)
On the 5th of November, 2020, the presidential delegation of Yonsei University, including Seoung Hwan Suh, the president visited IBS CNM. Jinwoo Choen, the director of IBS CNM greeted the delegation and gave a hall tour.
|[SF@Y] SF@Y Season 3! "Create NANO" (Sep 18, 2020)
Science Factory at Yonsei, Season 3, 2020 Summer
|[Event] The President of the IBS at IBS CNM (Aug 13, 2020)
Do Young Noh, the President of the Institute for Basic Science (IBS) visited IBS CNM
|[Event] IBS CNM with Institut Français Corée du Sud (Jul 28, 2020)
Science and Higher Education Officers of French Embassy(Institut Français Corée du Sud) visited IBS CNM to share passionate ideas with us